Associated Immunosuppression in a Dog Heterozygous for the MDR1 (ABCB1-1Δ) Mutation Abstract Pharmacodynamic monitoring was used to titrate cyclosporine dosing in a dog with immune-mediated hemolytic anemia. Development of a suspected secondary infection, with subsequent discovery of an unexpectedly high level of T-cell suppression despite a relatively low cyclosporine dose, prompted an investigation into the [...]
By Robette Johns Donna’s story highlights the fact that no matter how careful we are or how many times we tell our vet clinic our Collie is MDR1 mutant/mutant, it’s never enough. To give you a little background on the MDR1 journey, one of Pati Merrill’s memorable stories about “Getting to Know You”, in the [...]
Multidrug Sensitivity By Sue Floyd, VMD Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have a genetic predisposition to adverse drug reactions involving many different drugs. These drug sensitivities result from a mutation in the multidrug resistance gene (MDR1 gene.) Dogs with the mutant [...]