Associated Immunosuppression in a Dog Heterozygous for the MDR1 (ABCB1-1Δ) Mutation Abstract Pharmacodynamic monitoring was used to titrate cyclosporine dosing in a dog with immune-mediated hemolytic anemia. Development of a suspected secondary infection, with subsequent discovery of an unexpectedly high level of T-cell suppression despite a relatively low cyclosporine dose, prompted an investigation into the [...]
Multidrug Sensitivity By Sue Floyd, VMD Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have a genetic predisposition to adverse drug reactions involving many different drugs. These drug sensitivities result from a mutation in the multidrug resistance gene (MDR1 gene.) Dogs with the mutant [...]
The Interceptor Shortage – Today… Nancy Kelso, D.V.M Interceptor seems to have disappeared from the market completely. Sentinel (Interceptor and Program, a flea growth regulator) is now available. The main ingredient in Interceptor (milbemycin) is also available in Comboguard and Trifexis, with a flea prevention product, too, but no one is currently manufacturing milbemycin alone. [...]